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KMID : 0383820070620020134
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Tuberculosis and Respiratory Diseases
2007 Volume.62 No. 2 p.134 ~ p.139
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Gefitinib-Related Interstitial Pneumonia
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Lee Ho-Jin
Kim Chul-Hyun
Na Im-II
Lee Jae-Chul
Nam Seung-Bum
Jeong Jae-Wook
Ryu Baek-Ryul
Choe Du-Whan
Kang Jin-Hyung
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Abstract
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Gefitinib is a novel drug used to treat advanced non-small cell lung cancer. However, drug-related interstitial pneumonia is a major life-threatening side effect, which has a worldwide prevalence of 0.3-0.4%. In Japan, the prevalence is high as 3-4% but the actual frequency in Korea has not been officially assessed. We report two cases of gefitinib-induced interstitial lung disease during the treatment of non-small cell lung cancer. High-resolution computerized tomography (HRCT) of one case showed nonspecific ground glass opacity and the chest x-ray of another case showed diffuse bilateral ground glass opacity. The former patient showed a rapid good response to corticosteroid treatment whereas the latter died despite receiving aggressive treatment with high dose corticosteroid and empirical antibiotics.
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KEYWORD
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Gefitinib, Non-small cell Lung cancer, Interstitial pneumonia
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